Next-generation CRISPR tools and therapies improved by modified RNA guides

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), a gene-editing tool, is a promising way to treat diseases by removing, adding, or altering sections of deoxyribonucleic acid (DNA) sequences. It is currently the most straightforward, most flexible, and accurate method of gene manipulation.

A new type of gene-editing tool, CRISPR-Cas13, has shown promise in RNA targeting. Previous studies have shown the tool as a potential treatment method for viral diseases, including coronavirus disease (COVID-19).

Researchers at the lab of Neville Sanjana at New York University (NYU) and the New York Genome Center (NYGC) have developed chemically modified guide RNAs for a CRISPR system that targets RNA instead of DNA.

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Die nächste Generation